Website of Dr. Joseph George



Chapter in Books

1.

Joseph George, Mikihiro Tsutsumi, and Mutsumi Tsuchishima: Nanovesicle mediated delivery of anticancer agents effectively regressed intrahepatic tumors in athymic mice. Paper presented at the AACR New Horizons in Cancer Research Conference held on November 6-9, 2017 in Shanghai, China.

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2. Akiko Matsuda, Sayantan Maji, Joseph George, Irene Yan, and Tushar Patel. Hepatic delivery of therapeutic agents using biological nanoparticles. Paper presented at the Digestive Disease Week (DDW 2017) held on May 6-9, 2017 at McCormick Place, Chicago, IL, USA.
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3. Joseph George, Nobuhiko Hayashi, Mutsumi Tsuchishima, and Mikihiro Tsutsumi: Inhibition of gamma-glutamyl transpeptidase attenuates hepatic ischemia-reperfusion injury in rats. Paper presented at the Digestive Disease Week (DDW 2017) held on May 6-9, 2017 at McCormick Place, Chicago, IL, USA.
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4.

Joseph George, Nobuhiko Hayashi, Takashi Saito, Kazuaki Ozaki, Nobuyuki Toshikuni, Mutsumi Tsuchishima, and Mikihiro Tsutsumi: Nanovesicle mediated delivery of combination of anticancer agents effectively induced cell death in HCC cell lines. Paper presented at the International Liver Congress (EASL-ILC 2017) held on April 19-23, 2017 in Amsterdam, Netherlands.

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5.

Joseph George, Nobuhiko Hayashi, Takashi Saito, Kazuaki Ozaki, Nobuyuki Toshikuni, Mutsumi Tsuchishima, and Mikihiro Tsutsumi: Deletion of survivin sensitize human hepatocellular carcinoma cells to low doses of doxorubicin and induce apoptosis. Paper presented at the 108th Annual meeting of the American Association for Cancer Research (AACR) held on April 1- 5, 2017 in Washington, DC, USA.

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6.

Joseph George, Nobuhiko Hayashi, Nobuyuki Toshikuni, Mutsumi Tsuchishima and Mikihiro Tsutsumi: Serum osteopontin reflects the degree of liver fibrosis in patients with hepatitis C virus infection. Paper presented at the 66th Annual meeting of the American Association for the Study of Liver Diseases (AASLD) held on November 13-17, 2015 in San Francisco, CA, USA.

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7.

Joseph George, and Mikihiro Tsutsumi: Epigallocatechin gallate treatment decreases osteopontin expression and attenuates N-Nitrosodimethylamine induced hepatic fibrosis in rats. Paper presented at the 65th Annual meeting of the American Association for the Study of Liver Diseases (AASLD) held on November 7-11, 2014 in Boston, MA, USA.

  [Abstract]  
8. Mikihiro Tsutsumi, Joseph George, Nobuhiko Hayashi, Mutsumi Tsuchishima: Carbohydrate-Deficient Transferrin as a useful biomarker for differentiating nonalcoholic steatohepatitis from alcoholic hepatitis. Paper presented at the 8th International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis (ALPD) held on November 16-17, 2013 in New Delhi, India.
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9.

Nobuyuki Toshikuni, Kazuaki Ozaki, Joseph George, Mikihiro Tsutsumi, and Tomiyasu Arisawa: Serum endocan as a novel prognostic biomarker in hepatocellular carcinoma patients. Paper presented at the United European Gastroenterology Week (UEG Week 2013) held on October 12-16, 2013 in Berlin, Germany.

  [Abstract]  
10. Joseph George, Nobuhiko Hayashi, Masayoshi Takeuchi, Tomiyasu Arisawa, and Mikihiro Tsutsumi: Acetaldehyde-derived advanced glycation end-products promote alcoholic liver disease. Paper presented at the Digestive Disease Week (DDW 2013) held on May 18-21, 2013 in Orlando, FL, USA.
  [Abstract]  
11. Joseph George, Mutsumi Tsuchishima, Nobuyuki Toshikuni, Takashi Saito, and Mikihiro Tsutsumi: Ethanol and ageing promote pathogenesis of hepatocellular carcinoma in mice. Paper presented at the 104th Annual meeting of the American Association for Cancer Research (AACR) held on April 6-10, 2013 in Washington, DC, USA.
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12.

Joseph George, Nobuhiko Hayashi, Masayoshi Takeuchi, and Mikihiro Tsutsumi: Acetaldehyde-derived advanced glycation end-products promote alcoholic liver disease. Paper presented at the 7th International Symposium on Alcoholic Liver and Pancreatic Diseases (ALPD) and Cirrhosis held on September 6-7, 2012 in Beijing, China.

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13. Mikihiro Tsutsumi, Joseph George, Tomoe Nomura, Nobuhiko Hayashi, and Tomiyasu Arisawa: Serum osteopontin levels as a diagnostic marker for hepatic fibrosis. Paper presented at the 16th World Congress of International Society for Biomedical Research on Alcoholism (ISBRA) held on September 9-12, 2012 in Sapporo, Hokkaido, Japan.
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14. Joseph George, Naren L. Banik and Swapan K. Ray. Combination of temozolomide and nanotaxol inhibits cell invasion, angiogenesis and tumor growth in glioblastomas through cell cycle arrest. Paper presented at the 103rd Annual meeting of the American Association for Cancer Research (AACR) held on March 31-April 4, 2012 in Chicago, Illinois, USA.
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15.

Mutsumi Tsuchishima, Joseph George, Hisakazu Siroeda, Takashi Saito, Tomiyasu Arisawa and Mikihiro Tsutsumi: Mechanism of the pathogenesis of hepatocellular carcinoma during chronic administration of ethanol in mice. Paper presented at the 62nd Annual meeting of the American Association for the Study of Liver Diseases (AASLD) held on November 4-8, 2011 in San Francisco, CA, USA.

  [Abstract]  
16. Joseph George, Jeanine DfArmiento and Mikihiro Tsutsumi: Human MMP-1 transgene protects experimentally induced hepatic fibrosis in mice. Paper presented at the 62nd Annual meeting of the American Association for the Study of Liver Diseases (AASLD) held on November 4-8, 2011 in San Francisco, CA, USA.
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17. Joseph George, Tomoki Fukuyama, Nobuhiko Hayashi, Kazuaki Ozaki, Hisakazu Shiroeda, Tomiyasu Arisawa and Mikihiro Tsutsumi: Occasional alcohol intake promotes nonalcoholic steatohepatitis in obese rats. Paper presented at the 6th International Symposium on Alcoholic Liver and Pancreatic Diseases (ALPD) and Cirrhosis held on October 20-21, 2011 in Fukuoka, Japan.
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18. Mutsumi Tsuchishima, Joseph George, Takashi Saito, Nobuyuki Toshikuni, Tomiyasu Arisawa and Mikihiro Tsutsumi: Mechanism of the pathogenesis of hepatocellular carcinoma during chronic administration of ethanol in mice. Paper presented at the 6th International Symposium on Alcoholic Liver and Pancreatic Diseases (ALPD) and Cirrhosis held on October 20-21, 2011 in Fukuoka, Japan.
  [Abstract]  
19. Joseph George, Mikihiro Tsutsumi and Jeanine DfArmiento: Human MMP-1 transgene protects experimentally induced hepatic fibrosis in mice. Paper presented at the 21st Conference of the Asian Pacific Association for the Study of the Liver (APASL) held on February 17-20, 2011 in Bangkok, Thailand.
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20. Elena Arriazu, Tung Ming Leung, Suzanna Paganos, Joseph George, M. Isabel Fiel and Natalia Nieto: SPP1 contributes to non-alcoholic steatohepatitis in mice fed a methionine-choline deficient diet. Paper presented at the 61st Annual meeting of the American Association for the Study of Liver Diseases (AASLD) held on October 29-November 2, 2010 in Boston, MA, USA.
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21.

Aritz Lopategi, Joseph George and Natalia Nieto: Hepatic stellate cells secretes osteopontin under oxidative stress and contributes to fibrogenic response mediated through integrin ƒżvƒÀ3 and PI3K/pAkt pathway. Paper presented at the 61st Annual meeting of the American Association for the Study of Liver Diseases (AASLD) held on October 29-November 2, 2010 in Boston, MA, USA.

  [Abstract]  
22. Joseph George, M. Isabel Fiel and Natalia Nieto: Carbon tetrachloride-induced liver injury and fibrosis correlates with osteopontin expression in mice. Paper presented at the 61st Annual meeting of the American Association for the Study of Liver Diseases (AASLD) held on October 29-November 2, 2010 in Boston, MA, USA.
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23. Joseph George, Mikihiro Tsutsumi and Jeanine DfArmiento: MMP-13 deletion attenuates N-nitrosodimethylamine induced hepatic fibrosis in mice. Paper presented at the 61st Annual meeting of the American Association for the Study of Liver Diseases (AASLD) held on October 29-November 2, 2010 in Boston, MA, USA.
  [Abstract]  
24. Joseph George, Naren L. Banik and Swapan K. Ray. Knockdown of connective tissue growth factor and treatment with temozolomide inhibited invasion, angiogenesis, and tumorigenesis of human glioblastomas. Paper presented at the 101st Annual meeting of the American Association for Cancer Research (AACR) held on April 17-21, 2010 in Washington, DC, USA.
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25. Joseph George, Naren L. Banik and Swapan K. Ray. Combination of 4-HPR and EGCG induces apoptosis and inhibits angiogenesis and tumorigenesis of neuroblastoma SH-SY5Y and SK-N-DZ cells. Paper presented at the 101st Annual meeting of the American Association for Cancer Research (AACR) held on April 17-21, 2010 in Washington, DC, USA.
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26. Joseph George, Mikihiro Tsutsumi and Jeanine DfArmiento: MMP-13 deletion protects monocrotaline induced liver injury in mice. Paper presented at the 60th Annual meeting of the American Association for the Study of Liver Diseases (AASLD) held on October 30-November 3, 2009 in Boston, MA, USA.
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27. Joseph George, Jun Onodera, Teruo Miyata and Yuzo Tarumi. Biodegradable honeycomb collagen scaffold for dermal tissue engineering. Paper presented at the 2nd World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS) held on August 31-September 3, 2009 in Daejeon, South Korea.
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28. Joseph George, Naren L. Banik and Swapan K. Ray. Survivin knockdown enhanced efficacy of N-(4-hydroxyphenyl) retinamide for apoptosis in human glioblastoma U138MG and U251MG cells and inhibited invasion, angiogenesis and tumor growth. Paper presented at the 100th Annual meeting of the American Association for Cancer Research (AACR) held on April 18-22, 2009 in Denver, CO, USA.
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29. Joseph George, Naren L. Banik and Swapan K. Ray. Combination of 4-HPR and Genistein increases apoptosis in glioblastoma cells and inhibits invasion, angiogenesis, and tumor growth. Paper presented at the 40th Annual meeting of the American Society for Neurochemistry (ASN) held on March 7-11, 2009 in Charleston, SC, USA.
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30. Joseph George and Mikihiro Tsutsumi. Interfering of connective tissue growth factor mRNA protects N-nitrosodimethylamine induced toxic liver injury in rats. Paper presented at the 59th Annual meeting of the American Association for the Study of Liver Diseases (AASLD) held on October 31-November 4, 2008 in San Francisco, CA, USA.
  [Abstract]  
31. Joseph George and Mikihiro Tsutsumi. Elevated serum ƒÀ-glucuronidase reflects hepatic lysosomal fragility following toxic liver injury in rats. Paper presented at the 59th Annual meeting of the American Association for the Study of Liver Diseases (AASLD) held on October 31-November 4, 2008 in San Francisco, CA, USA.
  [Abstract]  
32. Joseph George, Naren L. Banik and Swapan K. Ray. Synergistic effect of Bcl-xL small interfering RNA and Genistein induces apoptosis, inhibits angiogenesis and tumor growth in SH-SY-5Y and SK-N-DZ Neuroblastoma Cells. Paper presented at the 99th Annual meeting of the American Association for Cancer Research (AACR) held on April 12-16, 2008 in San Diego, CA, USA.
  [Abstract]  
33. Joseph George, Naren L. Banik and Swapan K. Ray: siRNA Mediated knockdown of Bcl-2 and low-dose taxol treatment in U251MG glioblastoma cells induces apoptosis, inhibits cell invasion, angiogenesis and tumor growth. Paper presented at the 99th Annual meeting of the American Association for Cancer Research (AACR) held on April 12-16, 2008 in San Diego, CA, USA.
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34. Joseph George, Naren L. Banik and Swapan K. Ray. Simultaneous siRNA mediated downregulation of hTERT and treatment with interferon-g inhibits invasion, angiogenesis and tumor growth through cell cycle arrest in SNB-19 and LN-18 glioblastoma cells. Paper presented at the 99th Annual meeting of the American Association for Cancer Research (AACR) held on April 12-16, 2008 in San Diego, CA, USA.
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35. Joseph George, Naren L. Banik and Swapan K. Ray. siRNA mediated knockdown of Bcl-2 in human glioblastoma cell lines increased taxol mediated apoptosis. Paper presented at the 21st Biennial meeting of the International Society for Neurochemistry (ISN) and the 38th Annual Meeting of the American Society for Neurochemistry (ASN) held on August 19-24, 2007 in Cancun, Mexico.
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36. Joseph George, Christopher S. Gondi, Meena Gujrati, Dzung H. Dinh, and Jasti S. Rao. Restoration of TFPI-2 in a human glioblastoma cell line triggers caspase mediated pathway and apoptosis. Paper presented at the 98th Annual meeting of the American Association for Cancer Research (AACR) held on April 14-18, 2007 in Los Angels, CA, USA.
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37. Joseph George, Naren L. Banik and Swapan K. Ray. RNA interference during taxol treatment promotes apoptosis in a highly invasive human glioblastoma cell line. Paper presented at the 8th annual frontiers in neuroscience research (AFNR) day held on March 16, 2007 in Charleston, SC, USA.
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38. Joseph George, Christopher S. Gondi, Meena Gujrati, Dzung H. Dinh, William C. Olivero and Jasti S. Rao. Treatment with a recombinant adeno-associated virus expressing the TFPI-2 gene simultaneously downregulates MMP-9 and VEGF in a human glioblastoma cell line. Paper presented in the 97th Annual meeting of the American Association for Cancer Research (AACR) held on April 1-5, 2006 in Washington, DC, USA.
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39. Joseph George, Kazuki Nemoto, Teruo Miyata and Yoshinori Kuboki. Honeycomb collagen scaffold for the in vitro differentiation of mesenchymal stem cells into osteoblasts. Paper presented in the 5th Annual meeting of the Tissue Engineering Society International (TESI) held on December 8-10, 2002 in Kobe, Japan.
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40. Kazuki Nemoto, Hiroko Takita, Ryota Yoshimoto, Joseph George, Teruo Miyata and Yoshinori Kuboki. Geometry of honeycomb collagen scaffold gives chamber type microenvironmental units for ectopic osteogenesis when implanted with purified BMP cocktail into rat skin. Paper presented in the 5th Annual meeting of the Tissue Engineering Society International (TESI) held on December 8-10, 2002 in Kobe, Japan.
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41. Joseph George, Yu Aso and Teruo Miyata: Tissue engineered skin substitute on biodegradable honeycomb collagen scaffold. Paper presented in the 13th World Congress of International Society for Artificial Organs (ISAO) held on November 5-8, 2001 in Osaka, Japan.
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42. Joseph George and Gowri Chandrakasan:Curcumin inhibits stellate cell activation and hyaluronic acid accumulation in dimethylnitrosamine induced hepatic fibrosis in rats. Paper presented in the International Conference on New Strategies for the Treatment of Liver Cirrhosis held on June 7-9, 2001 in Tokyo, Japan.
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43. Onodera J., Saito A., George J., Iwasaki T., Ito H., Aso Y., Hamano T., Kanai A., Miyata T., Nagai Y: Application of atelocollagen solution for lacrimal duct occlusion. Paper presented in the 3rd International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevance held on November 15-18, 2000 in Maui, Hawaii, USA.
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44. Joseph George, Mikihiro Tsutsumi and Shujiro Takase: Expression of TIMP-1 and TIMP-2 in N-nitrosodimethylamine induced hepatic fibrosis in rats. Paper presented in the 51st Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) held on October 27-31, 2000 in Dallas, Texas, USA.
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45. Joseph George, Mikihiro Tsutsumi and Shujiro Takase: Mechanism of the increased serum level of hyaluronic acid in rats treated with nitrosodimethylamine. Paper presented in the joint meeting of the International Association for the Study of the Liver and Asian Pacific Association for the Study of the Liver (IASL-APASL) held on June 2-7, 2000 in Fukuoka, Japan.
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46. Anitha Balachander, Joseph George and Gowri Chandrakasan: Characterization of collagen types in cultured stellate cells from rat liver. Paper presented in the Keystone Symposia held on March 24-31, 2000 in Colorado, USA.
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47. Joseph George and Gowri Chandrakasan: Protective role of curcumin against dimethylnitrosamine induced hepatic fibrosis in rats. Paper presented in the 8th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Congress held on November 22-26, 1998 in Kuala Lumpur, Malaysia.
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48. Joseph George and Gowri Chandrakasan: Serum type III procollagen peptide and laminin P1 levels as a diagnostic tool for monitoring the progression of liver fibrosis and cirrhosis. Paper presented in the National Conference on Molecular Diagnostics held on June 27-29, 1998 in Trivandrum, India.
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49. Joseph George and Gowri Chandrakasan: Lysosomal fragility in dimethylnitrosamine induced liver injury in rats. Paper presented in the 66th Annual Meeting of the Society of Biological Chemists (SBC-India) held on December 22-24, 1997 in Visakhapatnam, India.
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50. Joseph George and Gowri Chandrakasan: Collagen metabolism in dimethylnitrosamine induced hepatic fibrosis in rats. Paper presented in the 17th International Congress of Biochemistry and Molecular Biology (FASEB) held on August 24-29, 1997 in San Francisco, USA.
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51. Joseph George, N. Anilkumar and Gowri Chandrakasan: Collagenolytic cathepsins in dimethylnitrosamine induced hepatic fibrosis in rats. Paper presented in the 65th Annual Meeting of the Society of Biological Chemists (SBC-India) held on November 20-23, 1996 in Bangalore, India.
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52. Joseph George, K. Ramesh Rao and Gowri Chandrakasan: Histopathological and biochemical alterations in dimethylnitrosamine induced liver injury in rats. Paper presented in the XVIIth Annual Conference of the Indian Association of Biomedical Scientists (IABMS) held on October 5-6, 1996 in Pondicherry, India.
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53. Joseph George and Gowri Chandrakasan: Biochemical studies on collagen during dimethylnitrosamine induced hepatic fibrosis. Paper presented in the XVIth Annual Conference of the Indian Association of Biomedical Scientists (IABMS) held on November 3-5, 1995 in Calcutta, India.
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54. Joseph George and Gowri Chandrakasan: Changes in serum and liver calcium, magnesium, potassium and sodium levels in dimethylnitrosamine induced hepatic fibrosis in rats. Paper presented in the 64th Annual Meeting of the Society of Biological Chemists (SBC-India) held on October 6-8, 1995 in Lucknow, India.
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55. Joseph George and Gowri Chandrakasan: Metabolism of liver collagen in dimethylnitrosamine induced hepatic fibrosis. Paper presented in the 19th Annual Conference of the Connective Tissue Society of Australia and New Zealand held on October 1-5, 1995 in Terrigal, New South Wales, Australia.
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56. Joseph George and Gowri Chandrakasan: Selenium levels in dimethylnitrosamine induced hepatic fibrosis in rats. Paper presented in the XVth Annual Conference of the Indian Association of Biomedical Scientists (IABMS) held on October 29-30, 1994 in Ootacamund, India.
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57. Joseph George and Gowri Chandrakasan: Molecular characteristics of dimethylnitrosamine induced fibrotic liver collagen. Paper presented in the international symposium on "Collagen: Structure, Biology and Technology" held on September 15-17, 1994 in Madras, India.
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58. Venkatesan N., Joseph George and Gowri Chandrakasan: Cyclophosphamide induced lung injury in rats. Paper presented in the 62nd Annual Meeting of the Society of Biological Chemists (SBC-India) held on December 19-22, 1993 in Madurai, India.
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59. Joseph George, N. Venkatesan and Gowri Chandrakasan: Molecular characteristics of fibrotic liver collagen in rats. Paper presented in the 62nd Annual Meeting of the Society of Biological Chemists (SBC-India) held on December 19-22, 1993 in Madurai, India.
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60. Joseph George and Gowri Chandrakasan: Biosynthesis of collagen during dimethylnitrosamine induced hepatic fibrosis in rats. Paper presented in the 61st Annual Meeting of the Society of Biological Chemists (SBC-India) held on December 21-23, 1992 in Hyderabad, India.
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61. Joseph George, N. Venkatesan and Gowri Chandrakasan: Histamine levels in dimethylnitrosamine induced hepatic fibrosis in rats. Paper presented in the XIIIth Annual Conference of the Indian Association of Biomedical Scientists (IABMS) held on September 19-20, 1992 in Trivandrum, India.
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62. Venkatesan, N., Joseph George and Gowri Chandrakasan: Angiotensin I converting enzyme activity in cyclophosphamide induced pulmonary fibrosis in rats. Paper presented in the XIIIth Annual Conference of the Indian Association of Biomedical Scientists (IABMS) held on September 19-20, 1992 in Trivandrum, India.
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63. Joseph George and Gowri Chandrakasan: Ascorbic acid levels in dimethylnitrosamine induced hepatic fibrosis in rats. Paper presented in the 27th Leather Research-Industry Get together held on January 28-30, 1992 in Madras, India.
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64. Joseph George, N. Venkatesan and Gowri Chandrakasan: Serum hydroxyproline levels in subtypes of leprosy. Paper presented in the Diamond Jubilee-Annual Meeting of the Society of Biological Chemists (SBC-India) held on December 26-30, 1991 in Calcutta, India.
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