Website of Dr. Joseph George




1.
Tamura K, Hayashi N, George J, Toshikuni N, Arisawa T, Hiratake J, Tsuchishima M, Tsutsumi M.
Abstract

GGsTop, a novel and specific γ-glutamyl transpeptidase inhibitor, protects hepatic ischemia-reperfusion injury in rats.
Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1;311(2):G305-12. doi: 10.1152/ajpgi.00439.2015. Epub 2016 Jun 30.
PMID: 27365338

2.
Toshikuni N, Ozaki K, George J, Tsutsumi M.
Abstract
Serum endocan as a survival predictor for patients with liver cirrhosis.
Can J Gastroenterol Hepatol. 2015 Nov-Dec;29(8):427-30. doi: 10.1155/2015/153805
PMID: 26669300 Free PMC Article
3.
Matsue Y, Tsutsumi M, Hayashi N, Saito T, Tsuchishima M, Toshikuni N, Arisawa T, George J.
Abstract

Serum osteopontin predicts degree of hepatic fibrosis and serves as a biomarker in patients with hepatitis C virus infection.
PLoS One. 2015 Mar 11;10(3):e0118744. doi: 10.1371/journal.pone.0118744
PMID: 25760884 [PubMed - indexed for MEDLINE]

4.
George J, Patel T.
Abstract

Noncoding RNA as therapeutic targets for hepatocellular carcinoma.
Semin Liver Dis. 2015 Feb;35(1):63-74. doi: 10.1055/s-0034-1397350. Epub 2015 Jan 29.
PMID: 25632936 [PubMed - indexed for MEDLINE]

5.
Minato T, Tsutsumi M, Tsuchishima M, Hayashi N, Saito T, Matsue Y, Toshikuni N, Arisawa T, George J.
Abstract

Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-induced simple steatosis.
Mol Med. 2014 Dec 10;20:490-502. doi: 10.2119/molmed.2014.00048
PMID: 25180626 [PubMed - indexed for MEDLINE]

6.
Ozaki K, Toshikuni N, George J, Minato T, Matsue Y, Arisawa T, Tsutsumi M.
Abstract

Serum endocan as a novel prognostic biomarker in patients with hepatocellular carcinoma.
J Cancer. 2014 Mar 4;5(3):221-30. doi: 10.7150/jca.7691
PMID: 24665346 [PubMed - indexed for MEDLINE]

7.
Hayashi N, George J, Takeuchi M, Fukumura A, Toshikuni N, Arisawa T, Tsutsumi M.
Abstract

Acetaldehyde-derived advanced glycation end-products promote alcoholic liver disease.
PLoS One. 2013 Jul 26;8(7):e70034. doi: 10.1371/journal.pone.0070034 Print 2013.
PMID: 23922897 [PubMed - indexed for MEDLINE]

8.

Tsuchishima M, George J, Shiroeda H, Arisawa T, Takegami T, Tsutsumi M.

Abstract

Chronic ingestion of ethanol induces hepatocellular carcinoma in mice without additional hepatic insult.
Dig Dis Sci. 2013 Jul;58(7):1923-33. doi: 10.1007/s10620-013-2574-4 Epub 2013 Jan 31.
PMID: 23371017 [PubMed - indexed for MEDLINE]

9.
Hayashi N, George J, Shiroeda H, Saito T, Toshikuni N, Tsuchishima M, Arisawa T, Tsutsumi M.
Abstract

Irsogladine maleate for the treatment of recurrent aphthous stomatitis in hepatitis C virus patients on pegylated-interferon and ribavirin: A pilot study.
J Gastroenterol Hepatol. 2013 Jun;28(6):1015-8. doi: 10.1111/jgh.12137
PMID: 23425065 [PubMed - indexed for MEDLINE]

10.
Urtasun R, Lopategi A, George J, Leung TM, Lu Y, Wang X, Ge X, Fiel MI, Nieto N.
Abstract

Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin (V)(3) engagement and PI3K/pAkt/NFB signaling.
Hepatology. 2012 Feb;55(2):594-608. doi: 10.1002/hep.24701
PMID: 21953216 [PubMed - indexed for MEDLINE]

11.
Mormone E, George J, Nieto N.
Abstract
Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches.
Chem Biol Interact. 2011 Sep 30;193(3):225-31. doi: 10.1016/j.cbi.2011.07.001
Epub 2011 Jul 22. Review.
PMID: 21803030 [PubMed - indexed for MEDLINE]
12.
George J, D'Armiento J.
Abstract
Transgenic expression of human matrix metalloproteinase-9 augments monocrotaline-induced pulmonary arterial hypertension in mice.
J Hypertens. 2011 Feb;29(2):299-308. doi: 10.1097/HJH.0b013e328340a0e4
PMID: 21063214 [PubMed - indexed for MEDLINE]
13.
George J, Banik NL, Ray SK.
Abstract
Survivin knockdown and concurrent 4-HPR treatment controlled human glioblastoma in vitro and in vivo.
Neuro Oncol. 2010 Nov;12(11):1088-101. doi: 10.1093/neuonc/noq079 Epub 2010 Aug 2. PMID: 20679253 [PubMed - indexed for MEDLINE]
14.
George J, Banik NL, Ray SK.
Abstract
Knockdown of hTERT and concurrent treatment with interferon-gamma inhibited proliferation and invasion of human glioblastoma cell lines.
Int J Biochem Cell Biol. 2010 Jul;42(7):1164-73. doi: 10.1016/j.biocel.2010.04.002 Epub 2010 Apr 13.
PMID: 20394835 [PubMed - indexed for MEDLINE]
15.
George J, Banik NL, Ray SK.
Abstract
Genistein induces receptor and mitochondrial pathways and increases apoptosis during BCL-2 knockdown in human malignant neuroblastoma SK-N-DZ cells.
J Neurosci Res. 2010 Mar;88(4):877-86. doi: 10.1002/jnr.22244
PMID: 19813266 [PubMed - indexed for MEDLINE]
16.
George J, Banik NL, Ray SK.
Abstract
Combination of hTERT knockdown and IFN-gamma treatment inhibited angiogenesis and tumor progression in glioblastoma.
Clin Cancer Res. 2009 Dec 1;15(23):7186-95. doi: 10.1158/1078-0432.CCR-09-1425 Epub 2009 Nov 24.
PMID: 19934306 [PubMed - indexed for MEDLINE]
17.
George J, Banik NL, Ray SK.
Abstract
Combination of taxol and Bcl-2 siRNA induces apoptosis in human glioblastoma cells and inhibits invasion, angiogenesis, and tumor growth.
J Cell Mol Med. 2009 Oct;13(10):4205-18. doi: 10.1111/j.1582-4934.2008.00539.x
PMID: 19473291 [PubMed - indexed for MEDLINE]
18.
George J, Banik NL, Ray SK.
Abstract
Bcl-2 siRNA augments taxol mediated apoptotic death in human glioblastoma U138MG and U251MG cells.
Neurochem Res. 2009 Jan;34(1):66-78. doi: 10.1007/s11064-008-9659-z Epub 2008 Mar 21.
PMID: 18357521 [PubMed - indexed for MEDLINE]
19.
George J, Onodera J, Miyata T.
Abstract
Biodegradable honeycomb collagen scaffold for dermal tissue engineering.
J Biomed Mater Res A. 2008 Dec 15;87(4):1103-11. doi: 10.1002/jbm.a.32277
PMID: 18792951 [PubMed - indexed for MEDLINE]
20.
George J.
Abstract
Elevated serum beta-glucuronidase reflects hepatic lysosomal fragility following toxic liver injury in rats.
Biochem Cell Biol. 2008 Jun;86(3):235-43. doi: 10.1139/o08-038
PMID: 18523484 [PubMed - indexed for MEDLINE]
21.
George J, Gondi CS, Dinh DH, Gujrati M, Rao JS.
Abstract
Restoration of tissue factor pathway inhibitor-2 in a human glioblastoma cell line triggers caspase-mediated pathway and apoptosis.
Clin Cancer Res. 2007 Jun 15;13(12):3507-17. doi: 10.1158/1078-0432.CCR-06-3023
PMID: 17575213 [PubMed - indexed for MEDLINE]
22.
George J, Tsutsumi M.
Abstract
siRNA-mediated knockdown of connective tissue growth factor prevents N-nitrosodimethylamine-induced hepatic fibrosis in rats.
Gene Ther. 2007 May;14(10):790-803. doi: 10.1038/sj.gt.3302929 Epub 2007 Mar 8.
PMID: 17344905 [PubMed - indexed for MEDLINE ]
23.
George J.
Abstract
Mineral metabolism in dimethylnitrosamine-induced hepatic fibrosis.
Clin Biochem. 2006 Oct;39(10):984-91. doi: 10.1016/j.clinbiochem.2006.07.002
PMID: 16959231 [PubMed - indexed for MEDLINE]
24.
Tsutsumi M, George J, Ishizawa K, Fukumura A, Takase S.
Abstract
Effect of chronic dietary ethanol in the promotion of N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in rats.
J Gastroenterol Hepatol. 2006 May;21(5):805-13. doi: 10.1111/j.1440-1746.2005.04040.x
PMID: 16704527 [PubMed - indexed for MEDLINE]
25.
George J, Kuboki Y, Miyata T.
Abstract
Differentiation of mesenchymal stem cells into osteoblasts on honeycomb collagen scaffolds. Biotechnol Bioeng. 2006 Oct 20;95(3):404-11. doi: 10.1002/bit.20939
PMID: 16572435 [PubMed - indexed for MEDLINE ]
26.
George J, Stern R.
Abstract
Serum hyaluronan and hyaluronidase: very early markers of toxic liver injury.
Clin Chim Acta. 2004 Oct;348(1-2):189-97. doi: 10.1016/j.cccn.2004.05.018
PMID: 15369754 [PubMed - indexed for MEDLINE]
27.
George J, Tsutsumi M, Takase S.
Abstract

Expression of hyaluronic acid in N-nitrosodimethylamine induced hepatic fibrosis in rats.
Int J Biochem Cell Biol. 2004 Feb;36(2):307-19. doi: 10.1016/S1357-2725(03)00253-x
PMID: 14643895 [PubMed - indexed for MEDLINE]

28.
George J.
Abstract
Ascorbic acid concentrations in dimethylnitrosamine-induced hepatic fibrosis in rats.
Clin Chim Acta. 2003 Sep;335(1-2):39-47. doi: 10.1016/S0009-8981(03)00285-7
PMID: 12927683 [PubMed - indexed for MEDLINE]
29.
Onodera J, Saito A, George J, Iwasaki T, Ito H, Aso Y, Hamano T,
Kanai A, Miyata T, Nagai Y.
No abstract
Application of atelocollagen solution for lacrimal duct occlusion.
Adv Exp Med Biol. 2002;506(Pt B):1277-81. No abstract available.
doi: 10.1097/00003226-200011002-00138
PMID: 12614067 [PubMed - indexed for MEDLINE]
30.
George J, Rao KR, Stern R, Chandrakasan G.
Abstract
Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen.
Toxicology. 2001 Jan 2;156(2-3):129-38. doi: 10.1016/S0300-483X(00)00352-8
PMID: 11164615 [PubMed - indexed for MEDLINE]
31.
George J, Chandrakasan G.
Abstract
Biochemical abnormalities during the progression of hepatic fibrosis induced by dimethylnitrosamine.
Clin Biochem. 2000 Oct;33(7):563-70. doi: 10.1016/S0009-9120(00)00170-3
PMID: 11124342 [PubMed - indexed for MEDLINE]
32.
George J, Chandrakasan G.
Abstract
Glycoprotein metabolism in dimethylnitrosamine induced hepatic fibrosis in rats.
Int J Biochem Cell Biol. 1996 Mar;28(3):353-61. doi: 10.1016/1357-2725(95)00140-9
PMID: 8920645 [PubMed - indexed for MEDLINE]
33.
George J, Chandrakasan G.
Abstract
Molecular characteristics of dimethylnitrosamine induced fibrotic liver collagen.
Biochim Biophys Acta. 1996 Feb 8;1292(2):215-22. doi: 10.1016/0167-4838(95)00202-2
PMID: 8597566 [PubMed - indexed for MEDLINE]
34.
George J, Bhatia VN, Balakrishnan S, Ramu G.
Abstract
Serum zinc/copper ratio in subtypes of leprosy and effect of oral zinc therapy on reactional states.
Int J Lepr Other Mycobact Dis. 1991 Mar;59(1):20-4.
PMID: 2030313 [PubMed - indexed for MEDLINE]
35.
George J, Rajendran M, Bhatia VN.
Abstract
Serum beta-glucuronidase in subtypes of leprosy.
Indian J Med Res. 1990 Mar;91:106-10.
PMID: 2345017 [PubMed - indexed for MEDLINE]
36.
George J, Balakrishnan S, Bhatia VN.
No abstract
Drug interaction during multidrug regimens for treatment of leprosy.
Indian J Med Res. 1988 Feb;87:151-6. No abstract available.
PMID: 3397146 [PubMed - indexed for MEDLINE]
37.
George J, Bhatia VN, Balakrishnan S.
Abstract
Microbiological assay versus spectrophotometry for determination of rifampicin in urine.
Indian J Lepr. 1988 Jan;60(1):47-52.
PMID: 3060546 [PubMed - indexed for MEDLINE]
38.
George J, Balakrishnan S.
Abstract
Blood dapsone levels in leprosy patients treated with acedapsone.
Indian J Lepr. 1986 Jul-Sep;58(3):401-6.
PMID: 3794408 [PubMed - indexed for MEDLINE]
39.
George J, Balakrishnan S, Bhatia VN, Anandan D, Harikrishnan S.
Abstract
Thyroglobulin autoantibodies in leprosy.
Indian J Lepr. 1986 Apr-Jun;58(2):191-5.
PMID: 3805790 [PubMed - indexed for MEDLINE]
40.
George J, Balakrishnan S.
Abstract
A comparative study of the haemagglutination inhibition (HI) test and spot test for detection of dapsone in urine.
Indian J Lepr. 1985 Jul-Sep;57(3):601-6.
PMID: 3831099 [PubMed - indexed for MEDLINE]


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