Website of Dr. Joseph George



1.
Saito T, George J, Ozaki K, Tsuchishima M, Tsutsumi M.
Abstract
 Pemafibrate modulates peroxisome proliferator-activated receptor alpha and prevents alcohol-associated liver disease in rats.
Mol Med. 2025 Apr 22;31(1):145. doi: 10.1186/s10020-025-01210-9. PMID: 40263984 PDF
2.
George J, Lu Y, Tsuchishima M, Tsutsumi M.
Abstract
 Cellular and molecular mechanisms of hepatic ischemia-reperfusion injury: The role of oxidative stress and therapeutic approaches.
Redox Biol. 2024 Jun 27;75:103258. doi:10.1016/j.redox.2024.103258. Online ahead of print. PMID: 38970988 Review. PDF
3.
Saito T, Tsuchishima M, Tsutsumi M, George J.
Abstract
 Molecular pathogenesis of metabolic dysfunction-associated steatotic liver disease, steatohepatitis, hepatic fibrosis and liver cirrhosis.
J Cell Mol Med. 2024 Jun; 28(12):e18491. doi: 10.1111/jcmm.18491.
Epub 2020 Jul 14.PMID:38894579 PDF
4.
Lu Y, George J.
Abstract
 Interaction between fatty acid oxidation and ethanol metabolism in liver.
Am J Physiol Gastrointest Liver Physiol. 2024 May 1;326(5):G483-G494. doi: 10.1152/ajpgi.00281.2023. Epub 2024 Mar 5. PMID: 38573193 Review. PDF
5
Yamagata M, Tsuchishima M, Saito T, Tsutsumi M, George J.
Abstract
 Therapeutic implication of human placental extract to prevent liver cirrhosis in rats with metabolic dysfunction-associated steatohepatitis.
Clin Sci (Lond). 2024 Mar 6;138(5):327-349. doi: 10.1042/CS20230533. PMID: 38381799 PDF
6.
Nomura M, George J, Hashizume C, Saito T, Ueda Y, Ishigaki Y, Tsuchishima M, Tsutsumi M.
Abstract
 Surgical implantation of human adipose derived stem cells attenuates experimentally induced hepatic fibrosis in rats.
Mol Med. 2022 Nov 29;28(1):143. doi: 10.1186/s10020-022-00566-6.
PMID: 36447136 PDF Free PMC article.
7.
George J, Tsuchishima M, Tsutsumi M.
Abstract
 Epigallocatechin-3-gallate inhibits osteopontin expression and prevents experimentally induced hepatic fibrosis.
Biomed Pharmacother. 2022 Jul;151:113111. doi: 10.1016/j.biopha.2022.113111. Epub 2022 May 17. PMID: 35594711 PDF Free Article
8.
Kubota R, Hayashi N, Kinoshita K, Saito T, Ozaki K, Ueda Y, Tsuchishima M, Tsutsumi M, George J.
Abstract
 Inhibition of gamma-glutamyltransferase ameliorates ischemia- reoxygenation tissue damage in rats with hepatic steatosis.
Br J Pharmacol. 2020 Sep 10; 177(22):5195-207. doi: 10.1111/bph.15258. Online ahead of print. PMID: 32910829 PDF
9.
George J, Tsuchishima M, Tsutsumi M.
Abstract
 Metabolism of N-nitrosodimethylamine, methylation of macromolecules, and development of hepatic fibrosis in rodent models.
J Mol Med (Berl). 2020 Sep;98(9):1203-1213. doi: 10.1007/s00109-020-01950-7.
Epub 2020 Jul 14.PMID: 32666246 Review. PDF
10.
George J.
Abstract
 Metabolism and interactions of antileprosy drugs.
Biochem Pharmacol. 2020 July;177:113993. doi: 10.1016/j.bcp.2020.113993 Epub 2020 Apr 24. PMID: 32339493 PDF
11.
Hirakawa Y, Tsuchishima M, Fukumura A, Kinoshita K, Hayashi N, Saito T, George J, Toshikuni N, Ueda Y, Tsutsumi M.
Abstract
 Recombinant thrombomodulin prevented hepatic ischemia-reperfusion injury by inhibiting high-mobility group box 1 in rats.
Eur J Pharmacol. 2019 Nov 15; 863:172681. doi: 10.1016/j.ejphar.2019.172681 Epub 2019 Sep 19. PMID: 31542482 PDF
12.
George J, Tsutsumi M, Tsuchishima M.
Abstract
 Alteration of Trace Elements during Pathogenesis of N-Nitrosodimethylamine Induced Hepatic Fibrosis.
Sci Rep. 2019 Jan 24;9(1):708. doi: 10.1038/s41598-018-37516-4.
PMID: 30679730 PDF
13.
George J, Tsuchishima M, Tsutsumi M.
Abstract
 Molecular mechanisms in the pathogenesis of N-nitrosodimethylamine induced hepatic fibrosis.
Cell Death Dis. 2019 Jan 8;10(1):18. doi: 10.1038/s41419-018-1272-8.
PMID: 30622238 Free PMC Article PDF
14.
George J, Yan IK, Patel T.
Abstract
 Nanovesicle-mediated delivery of anticancer agents effectively induced cell death and regressed intrahepatic tumors in athymic mice.
Lab Invest. 2018 Jul;98(7):895-910. doi: 10.1038/s41374-018-0053-4. Epub 2018 May 10.
PMID: 29748614 PDF
15.
George J.
Abstract
 Determination of selenium during pathogenesis of hepatic fibrosis employing hydride generation and inductively coupled plasma mass spectrometry.
Biol Chem. 2018 Apr 25;399(5):499-509. doi: 10.1515/hsz-2017-0260.
PMID: 29408794 PDF
16.
George J, Tsutsumi M, Tsuchishima M.
Abstract

MMP-13 deletion decreases profibrogenic molecules and attenuates N-nitrosodimethylamine-induced liver injury and fibrosis in mice.
J Cell Mol Med. 2017 Dec;21(12):3821-3835. doi: 10.1111/jcmm.13304. Epub 2017 Aug 7.
PMID: 28782260 Free PMC Article PDF
17.
Tamura K, Hayashi N, George J, Toshikuni N, Arisawa T, Hiratake J, Tsuchishima M, Tsutsumi M.
Abstract

GGsTop, a novel and specific γ-glutamyl transpeptidase inhibitor, protects hepatic ischemia-reperfusion injury in rats.
Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1;311(2):G305-12. doi: 10.1152/ajpgi.00439.2015 Epub 2016 Jun 30.
PMID: 27365338 Free PMC Article PDF
18.
Toshikuni N, Ozaki K, George J, Tsutsumi M.
Abstract
 Serum endocan as a survival predictor for patients with liver cirrhosis.
Can J Gastroenterol Hepatol. 2015 Nov-Dec;29(8):427-30. doi: 10.1155/2015/153805
PMID: 26669300 Free PMC Article PDF
19.
Matsue Y, Tsutsumi M, Hayashi N, Saito T, Tsuchishima M, Toshikuni N, Arisawa T, George J.
Abstract

Serum osteopontin predicts degree of hepatic fibrosis and serves as a biomarker in patients with hepatitis C virus infection.
PLoS One. 2015 Mar 11;10(3):e0118744. doi: 10.1371/journal.pone.0118744
PMID: 25760884 [PubMed - indexed for MEDLINE] PDF
20.
George J, Patel T.
Abstract

Noncoding RNA as therapeutic targets for hepatocellular carcinoma.
Semin Liver Dis. 2015 Feb;35(1):63-74. doi: 10.1055/s-0034-1397350. Epub 2015 Jan 29.
PMID: 25632936 [PubMed - indexed for MEDLINE] PDF
21.
Minato T, Tsutsumi M, Tsuchishima M, Hayashi N, Saito T, Matsue Y, Toshikuni N, Arisawa T, George J.
Abstract

Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-induced simple steatosis.
Mol Med. 2014 Dec 10;20:490-502. doi: 10.2119/molmed.2014.00048
PMID: 25180626 [PubMed - indexed for MEDLINE] PDF
22.
Ozaki K, Toshikuni N, George J, Minato T, Matsue Y, Arisawa T, Tsutsumi M.
Abstract

Serum endocan as a novel prognostic biomarker in patients with hepatocellular carcinoma.
J Cancer. 2014 Mar 4;5(3):221-30. doi: 10.7150/jca.7691
PMID: 24665346 [PubMed - indexed for MEDLINE] PDF
23.
Hayashi N, George J, Takeuchi M, Fukumura A, Toshikuni N, Arisawa T, Tsutsumi M.
Abstract

Acetaldehyde-derived advanced glycation end-products promote alcoholic liver disease.
PLoS One. 2013 Jul 26;8(7):e70034. doi: 10.1371/journal.pone.0070034 Print 2013.
PMID: 23922897 [PubMed - indexed for MEDLINE] PDF
24.

Tsuchishima M, George J, Shiroeda H, Arisawa T, Takegami T, Tsutsumi M.

Abstract

Chronic ingestion of ethanol induces hepatocellular carcinoma in mice without additional hepatic insult.
Dig Dis Sci. 2013 Jul;58(7):1923-33. doi: 10.1007/s10620-013-2574-4 Epub 2013 Jan 31.
PMID: 23371017 [PubMed - indexed for MEDLINE] PDF
25.
Hayashi N, George J, Shiroeda H, Saito T, Toshikuni N, Tsuchishima M, Arisawa T, Tsutsumi M.
Abstract

Irsogladine maleate for the treatment of recurrent aphthous stomatitis in hepatitis C virus patients on pegylated-interferon and ribavirin: A pilot study.
J Gastroenterol Hepatol. 2013 Jun;28(6):1015-8. doi: 10.1111/jgh.12137
PMID: 23425065 [PubMed - indexed for MEDLINE] PDF
26.
Urtasun R, Lopategi A, George J, Leung TM, Lu Y, Wang X, Ge X, Fiel MI, Nieto N.
Abstract

Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin ƒ¿(V)ƒÀ(3) engagement and PI3K/pAkt/NFƒÈB signaling.
Hepatology. 2012 Feb;55(2):594-608. doi: 10.1002/hep.24701
PMID: 21953216 [PubMed - indexed for MEDLINE] PDF
27.
Mormone E, George J, Nieto N.
Abstract
 Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches.
Chem Biol Interact. 2011 Sep 30;193(3):225-31. doi: 10.1016/j.cbi.2011.07.001
Epub 2011 Jul 22. Review.
PMID: 21803030 [PubMed - indexed for MEDLINE] PDF
28.
George J, D'Armiento J.
Abstract
 Transgenic expression of human matrix metalloproteinase-9 augments monocrotaline-induced pulmonary arterial hypertension in mice.
J Hypertens. 2011 Feb;29(2):299-308. doi: 10.1097/HJH.0b013e328340a0e4
PMID: 21063214 [PubMed - indexed for MEDLINE] PDF
29.
George J, Banik NL, Ray SK.
Abstract
 Survivin knockdown and concurrent 4-HPR treatment controlled human glioblastoma in vitro and in vivo.
Neuro Oncol. 2010 Nov;12(11):1088-101. doi: 10.1093/neuonc/noq079 Epub 2010 Aug 2. PMID: 20679253 [PubMed - indexed for MEDLINE] PDF
30.
George J, Banik NL, Ray SK.
Abstract
 Knockdown of hTERT and concurrent treatment with interferon-gamma inhibited proliferation and invasion of human glioblastoma cell lines.
Int J Biochem Cell Biol. 2010 Jul;42(7):1164-73. doi: 10.1016/j.biocel.2010.04.002 Epub 2010 Apr 13.
PMID: 20394835 [PubMed - indexed for MEDLINE] PDF
31.
George J, Banik NL, Ray SK.
Abstract
 Genistein induces receptor and mitochondrial pathways and increases apoptosis during BCL-2 knockdown in human malignant neuroblastoma SK-N-DZ cells.
J Neurosci Res. 2010 Mar;88(4):877-86. doi: 10.1002/jnr.22244
PMID: 19813266 [PubMed - indexed for MEDLINE] PDF
32.
George J, Banik NL, Ray SK.
Abstract
 Combination of hTERT knockdown and IFN-gamma treatment inhibited angiogenesis and tumor progression in glioblastoma.
Clin Cancer Res. 2009 Dec 1;15(23):7186-95. doi: 10.1158/1078-0432.CCR-09-1425 Epub 2009 Nov 24.
PMID: 19934306 [PubMed - indexed for MEDLINE] PDF
33.
George J, Banik NL, Ray SK.
Abstract
 Combination of taxol and Bcl-2 siRNA induces apoptosis in human glioblastoma cells and inhibits invasion, angiogenesis, and tumor growth.
J Cell Mol Med. 2009 Oct;13(10):4205-18. doi: 10.1111/j.1582-4934.2008.00539.x
PMID: 19473291 [PubMed - indexed for MEDLINE] PDF
34.
George J, Banik NL, Ray SK.
Abstract
 Bcl-2 siRNA augments taxol mediated apoptotic death in human glioblastoma U138MG and U251MG cells.
Neurochem Res. 2009 Jan;34(1):66-78. doi: 10.1007/s11064-008-9659-z Epub 2008 Mar 21.
PMID: 18357521 [PubMed - indexed for MEDLINE] PDF
35.
George J, Onodera J, Miyata T.
Abstract
 Biodegradable honeycomb collagen scaffold for dermal tissue engineering.
J Biomed Mater Res A. 2008 Dec 15;87(4):1103-11. doi: 10.1002/jbm.a.32277
PMID: 18792951 [PubMed - indexed for MEDLINE] PDF
36.
George J.
Abstract
 Elevated serum beta-glucuronidase reflects hepatic lysosomal fragility following toxic liver injury in rats.
Biochem Cell Biol. 2008 Jun;86(3):235-43. doi: 10.1139/o08-038
PMID: 18523484 [PubMed - indexed for MEDLINE] PDF
37.
George J, Gondi CS, Dinh DH, Gujrati M, Rao JS.
Abstract
 Restoration of tissue factor pathway inhibitor-2 in a human glioblastoma cell line triggers caspase-mediated pathway and apoptosis.
Clin Cancer Res. 2007 Jun 15;13(12):3507-17. doi: 10.1158/1078-0432.CCR-06-3023
PMID: 17575213 [PubMed - indexed for MEDLINE] PDF
38.
George J, Tsutsumi M.
Abstract
 siRNA-mediated knockdown of connective tissue growth factor prevents N-nitrosodimethylamine-induced hepatic fibrosis in rats.
Gene Ther. 2007 May;14(10):790-803. doi: 10.1038/sj.gt.3302929 Epub 2007 Mar 8.
PMID: 17344905 [PubMed - indexed for MEDLINE ] PDF
39.
George J.
Abstract
 Mineral metabolism in dimethylnitrosamine-induced hepatic fibrosis.
Clin Biochem. 2006 Oct;39(10):984-91. doi: 10.1016/j.clinbiochem.2006.07.002
PMID: 16959231 [PubMed - indexed for MEDLINE] PDF
40.
Tsutsumi M, George J, Ishizawa K, Fukumura A, Takase S.
Abstract
 Effect of chronic dietary ethanol in the promotion of N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in rats.
J Gastroenterol Hepatol. 2006 May;21(5):805-13. doi: 10.1111/j.1440-1746.2005.04040.x
PMID: 16704527 [PubMed - indexed for MEDLINE] PDF
41.
George J, Kuboki Y, Miyata T.
Abstract
 Differentiation of mesenchymal stem cells into osteoblasts on honeycomb collagen scaffolds. Biotechnol Bioeng. 2006 Oct 20;95(3):404-11. doi: 10.1002/bit.20939
PMID: 16572435 [PubMed - indexed for MEDLINE ] PDF
42.
George J, Stern R.
Abstract
 Serum hyaluronan and hyaluronidase: very early markers of toxic liver injury.
Clin Chim Acta. 2004 Oct;348(1-2):189-97. doi: 10.1016/j.cccn.2004.05.018
PMID: 15369754 [PubMed - indexed for MEDLINE] PDF
43.
George J, Tsutsumi M, Takase S.
Abstract

Expression of hyaluronic acid in N-nitrosodimethylamine induced hepatic fibrosis in rats.
Int J Biochem Cell Biol. 2004 Feb;36(2):307-19. doi: 10.1016/S1357-2725(03)00253-x
PMID: 14643895 [PubMed - indexed for MEDLINE] PDF
44.
George J.
Abstract
 Ascorbic acid concentrations in dimethylnitrosamine-induced hepatic fibrosis in rats.
Clin Chim Acta. 2003 Sep;335(1-2):39-47. doi: 10.1016/S0009-8981(03)00285-7
PMID: 12927683 [PubMed - indexed for MEDLINE] PDF
45.
Onodera J, Saito A, George J, Iwasaki T, Ito H, Aso Y, Hamano T,
Kanai A, Miyata T, Nagai Y.
No abstract
 Application of atelocollagen solution for lacrimal duct occlusion.
Adv Exp Med Biol. 2002;506(Pt B):1277-81. No abstract available.
doi: 10.1097/00003226-200011002-00138
PMID: 12614067 [PubMed - indexed for MEDLINE] PDF
46.
George J, Rao KR, Stern R, Chandrakasan G.
Abstract
 Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen.
Toxicology. 2001 Jan 2;156(2-3):129-38. doi: 10.1016/S0300-483X(00)00352-8
PMID: 11164615 [PubMed - indexed for MEDLINE] PDF
47.
George J, Chandrakasan G.
Abstract
 Biochemical abnormalities during the progression of hepatic fibrosis induced by dimethylnitrosamine.
Clin Biochem. 2000 Oct;33(7):563-70. doi: 10.1016/S0009-9120(00)00170-3
PMID: 11124342 [PubMed - indexed for MEDLINE] PDF
48.
George J, Chandrakasan G.
Abstract
 Glycoprotein metabolism in dimethylnitrosamine induced hepatic fibrosis in rats.
Int J Biochem Cell Biol. 1996 Mar;28(3):353-61. doi: 10.1016/1357-2725(95)00140-9
PMID: 8920645 [PubMed - indexed for MEDLINE] PDF
49.
George J, Chandrakasan G.
Abstract
 Molecular characteristics of dimethylnitrosamine induced fibrotic liver collagen.
Biochim Biophys Acta. 1996 Feb 8;1292(2):215-22. doi: 10.1016/0167-4838(95)00202-2
PMID: 8597566 [PubMed - indexed for MEDLINE] PDF
50.
George J, Bhatia VN, Balakrishnan S, Ramu G.
Abstract
 Serum zinc/copper ratio in subtypes of leprosy and effect of oral zinc therapy on reactional states.
Int J Lepr Other Mycobact Dis. 1991 Mar;59(1):20-4.
PMID: 2030313 [PubMed - indexed for MEDLINE] PDF
51.
George J, Rajendran M, Bhatia VN.
Abstract
 Serum beta-glucuronidase in subtypes of leprosy.
Indian J Med Res. 1990 Mar;91:106-10.
PMID: 2345017 [PubMed - indexed for MEDLINE] PDF
52.
George J, Balakrishnan S, Bhatia VN.
No abstract
 Drug interaction during multidrug regimens for treatment of leprosy.
Indian J Med Res. 1988 Feb;87:151-6. No abstract available.
PMID: 3397146 [PubMed - indexed for MEDLINE] PDF
53.
George J, Bhatia VN, Balakrishnan S.
Abstract
 Microbiological assay versus spectrophotometry for determination of rifampicin in urine.
Indian J Lepr. 1988 Jan;60(1):47-52.
PMID: 3060546 [PubMed - indexed for MEDLINE] PDF
54.
George J, Balakrishnan S.
Abstract
 Blood dapsone levels in leprosy patients treated with acedapsone.
Indian J Lepr. 1986 Jul-Sep;58(3):401-6.
PMID: 3794408 [PubMed - indexed for MEDLINE] PDF
55.
George J, Balakrishnan S, Bhatia VN, Anandan D, Harikrishnan S.
Abstract
 Thyroglobulin autoantibodies in leprosy.
Indian J Lepr. 1986 Apr-Jun;58(2):191-5.
PMID: 3805790 [PubMed - indexed for MEDLINE] PDF
56.
George J, Balakrishnan S.
Abstract
 A comparative study of the haemagglutination inhibition (HI) test and spot test for detection of dapsone in urine.
Indian J Lepr. 1985 Jul-Sep;57(3):601-6.
PMID: 3831099 [PubMed - indexed for MEDLINE] PDF


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